Article

<i>Ezh2</i> knockout in B cells impairs plasmablast differentiation and ameliorates lupus-like disease in MRL/ <i>lpr</i> mice

2022-07-22

Abstract excerpt

<h4>Objectives</h4> Enhancer of zeste homolog 2 (EZH2) regulates B cell development and differentiation. We have previously demonstrated increased EZH2 expression in peripheral blood mononuclear cells isolated from lupus patients. The goal of this study was to evaluate the role of B cell EZH2 expression in lupus pathogenesis. <h4>Methods</h4> We generated an MRL/ lpr mouse with floxed Ezh2 , which was crossed...

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Literature Corpus work: 8f8b11d5-406c-5fa1-9a3e-1051772a240c
DOI: 10.1101/2022.07.21.500990

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