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Article

The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells.

The Journal of experimental medicine - 21 Dec 1998

Dinkel A, Warnatz K, Ledermann B, Rolink A, Zipfel P F, Bürki K, Eibel H

Abstract excerpt

In mature B lymphocytes, the zinc finger transcription factor early growth response 1 (Egr-1) is one of the many immediate-early genes induced upon B cell antigen receptor engagement. However, its role during earlier stages of lymphopoiesis has remained unclear. By examining bone marrow B cell subsets, we found Egr-1 transcripts in pro/pre-B and immature B lymphocytes, and Egr-1 protein in pro/pre-B-I cells...

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Identifiers

PMID: 9858508
DOI: 10.1084/jem.188.12.2215
PMCID: PMC2212439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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