Article
The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells.
The Journal of experimental medicine - 21 Dec 1998
Dinkel A, Warnatz K, Ledermann B, Rolink A, Zipfel P F, Bürki K, Eibel H
Abstract excerpt
In mature B lymphocytes, the zinc finger transcription factor early growth response 1 (Egr-1) is one of the many immediate-early genes induced upon B cell antigen receptor engagement. However, its role during earlier stages of lymphopoiesis has remained unclear. By examining bone marrow B cell su...
Topics
- Animals
- B-Lymphocytes
- Bone Marrow Cells
- Cell Differentiation
- Cell Division
- Cell Line
- DNA
- DNA-Binding Proteins
- Early Growth Response Protein 1
- Female
- Gene Expression
- Gene Expression Regulation
- Hematopoietic Stem Cells
- Immediate-Early Proteins
- Leukopoiesis
- Liver
- Male
- Metalloendopeptidases