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Inducible deletion of <i>Ezh2</i> in CD4+ T cells inhibits kidney T cell infiltration and prevents interstitial nephritis in MRL/ <i>lpr</i> lupus-prone mice

2024-03-07

Abstract excerpt

Systemic lupus erythematosus is a remitting relapsing autoimmune disease characterized by autoantibody production and multi-organ involvement. T cell epigenetic dysregulation plays an important role in the pathogenesis of lupus. We have previously demonstrated upregulation of the key epigenetic regulator EZH2 in CD4+ T cells isolated from lupus patients. To further investigate the role of EZH2 in the pathogenesis...

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Literature Corpus work
0ebd2406-401e-5363-a308-1a90783f33d9
DOI
10.1101/2024.03.04.583401
Open publication

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Inducible deletion of <i>Ezh2</i> in CD4+ T cells inhibits kidney T cell infiltration and prevents interstitial nephritis in MRL/ <i>lpr</i> lupus-prone miceDOI 10.1101/2024.03.04.583401
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