Article

The transcription factor Zeb2 drives formation of age-associated B cells

2021-07-24

Abstract excerpt

Age-associated B-cells (ABCs) accumulate during infection, aging and autoimmunity, contributing to lupus pathogenesis. Here, we screen for transcription factors driving ABC formation and find Zeb2 is required for human and mouse ABC differentiation in-vitro. ABCs are reduced in ZEB2 haploinsufficient individuals and in mice lacking Zeb2 in B-cells. In mice with TLR7-driven lupus, Zeb2 is essential for ABC formatio...

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Literature Corpus work: 36664a74-af10-5d6c-91d3-b8cf221fd589
DOI: 10.1101/2021.07.24.453633

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