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Developmental Stage and Cellular Context Determine Oncogenic and Molecular Outcomes of <i>Ezh2</i> <sup>Y641F</sup> Mutation in Hematopoiesis

2024-11-15

Abstract excerpt

Mutations in the histone methyltransferase EZH2, particularly the Y641 hotspot mutation, have been implicated in hematologic malignancies, yet the effect of timing and cellular context on their oncogenic potential has remained unknown. In this study, we utilized a conditional allele with tissue-specific Cre drivers to investigate the effects of Ezh2 Y641F mutations at various stages of development, with a focus o...

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Literature Corpus work
a7cc426e-fc88-5e49-b055-9bd3101d886d
DOI
10.1101/2024.11.14.622807
Open publication

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