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Article

Emerging role of EZH2 in rheumatic diseases: A comprehensive review

7 Aug 2022

Abstract excerpt

Enhancer of zeste homolog 2 (EZH2) is a histone methylated enzyme. It trimethylates histone 3 lysine 27 (H3K27) to regulate epigenetic processes. Recently, studies showed excessive expression of EZH2 in rheumatic diseases, such as systemic lupus erythematosus, rheumatoid arthritis, osteoarthritis, and systemic sclerosis. Moreover, epigenetic modification of EZH2 regulates differentiation and proliferation of...

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PMID: 35933601
DOI: 10.1111/1756-185x.14416

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