Article
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.
Cancer cell - 13 May 2013
Béguelin Wendy, Popovic Relja, Teater Matt, Jiang Yanwen, Bunting Karen L, Rosen Monica, Shen Hao, Yang Shao Ning, Wang Ling, Ezponda Teresa, Martinez-Garcia Eva, Zhang Haikuo, Zheng Yupeng, Verma Sharad K, McCabe Michael T, Ott Heidi M, Van Aller Glenn S, Kruger Ryan G, Liu Yan, McHugh Charles F, Scott David W, Chung Young Rock, Kelleher Neil, Shaknovich Rita, Creasy Caretha L, Gascoyne Randy D, Wong Kwok-Kin, Cerchietti Leandro, Levine Ross L, Abdel-Wahab Omar, Licht Jonathan D, Elemento Olivier, Melnick Ari M
Abstract excerpt
The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and targeted by somatic mutations in B cell lymphomas. Here, we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions. EZH2 represses proliferation checkpoint genes and helps establish bivalent chromatin domains at key regulatory loci to transiently suppress GC B cell differentiation. Somatic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.