Biophysical fitness landscape design traps viral evolution

Abstract excerpt

<h4> A bstract </h4> Evolutionary adaptation is often visualized as a population’s stochastic climb toward the top of a fitness landscape. While there exist approaches to design or synthetically evolve proteins into desired structures, there is a lack of methodology for designing, tuning, and quantitatively reshaping the fitness landscapes themselves on which protein evolution takes place. Here, we introduce fo...

Topics

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• Antibodies, Viral
• COVID-19
• Evolution, Molecular
• Genetic Fitness
• Immune Evasion
• Mutation
• SARS-CoV-2
• Spike Glycoprotein, Coronavirus

Identifiers and source

Literature Corpus work

8f8a9e3a-7d0e-555b-ac73-aefb0ca127e6

DOI

10.1101/2025.03.30.646233