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Article

Fitness landscape of the human immunodeficiency virus envelope protein that is targeted by antibodies.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jan 2018

Louie Raymond H Y, Kaczorowski Kevin J, Barton John P, Chakraborty Arup K, McKay Matthew R

Abstract excerpt

HIV is a highly mutable virus, and over 30 years after its discovery, a vaccine or cure is still not available. The isolation of broadly neutralizing antibodies (bnAbs) from HIV-infected patients has led to renewed hope for a prophylactic vaccine capable of combating the scourge of HIV. A major challenge is the design of immunogens and vaccination protocols that can elicit bnAbs that target regions of the virus's...

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Share to Antibodies, Neutralizing
Share to Binding Sites, Antibody

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4 Antigens

Share to Computer Simulation

Share to Genetic Fitness

Share to HIV Envelope Protein gp160

Share to Immune Evasion

Share to Models, Genetic

Source

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Identifiers

PMID: 29311326
DOI: 10.1073/pnas.1717765115
PMCID: PMC5789945

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