Article

Deep Evolutionary Fitness Inference for Variant Nomination from Directed Evolution

2025-07-26

Abstract excerpt

Iterative screening techniques, such as directed evolution, enable high-throughput affinity maturation to optimize binders to molecular interfaces. However, the decision problem of selecting variants from rich, evolved populations to enter low-throughput follow-up methods remains a significant bottleneck. Here, we present evolutionary fitness inference (EVFI) and DeepEVFI, two machine learning methods that model d...

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Literature Corpus work: 60cc8028-e08e-5943-aa25-9b501b0fe256
DOI: 10.1101/2025.07.22.666175

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