Design of an immunogen containing multidimensionally conserved and immunogenic parts of the HIV proteome.

Abstract excerpt

Despite decades of research, an effective HIV vaccine or cure has not yet been developed. An important reason is the virus's mutability, which allows it to rapidly evade human immune responses. Often, the virus also takes advantage of epistatic pathways to evolve escape mutations through compensatory effects that allow maintaining its fitness. We used a fitness landscape of HIV, which explicitly considers...

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