Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constrained evolutionary funnels shape viral immune escape.

Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2026

Huot Marian, Wang Dianzhuo, Shakhnovich Eugene, Monasson Rémi, Cocco Simona

Abstract excerpt

Understanding how viral proteins adapt under immune pressure while preserving viability is crucial for anticipating antibody-resistant variants. We present a probabilistic framework that predicts viral escape trajectories and shows that immune evasion is channeled into a small set of viable "escape funnels" within the vast mutational space. These escape funnels arise from the combined constraints of protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Antibodies, Viral
Share to COVID-19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Immune Evasion

Share to SARS-CoV-2

Share to Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 41984829
DOI: 10.1073/pnas.2536956123
PMCID: PMC13099613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constrained evolutionary funnels shape viral immune escape.PMID 41984829Read ↗

Evaluating SARS-CoV-2 Antibody Resilience via Prediction and Design of Escape Viral VariantsSemantic proximity Read ↗

Biophysical fitness landscape design traps viral evolutionSemantic proximity Read ↗

Clonal interference and changing selective pressures shape the escape of SARS-CoV-2 from hundreds of antibodiesSemantic proximity Read ↗

Evolutionary Landscapes of Host-Virus Arms Races.Semantic proximity Read ↗

Natural selection driven by escape from shifting antibody classes shapes SARS-CoV-2 evolutionSemantic proximity Read ↗

Evolutionary dynamics of escape from biomedical intervention.Semantic proximity Read ↗

Learning from prepandemic data to forecast viral escape.Semantic proximity Read ↗

Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations.Semantic proximity Read ↗

Synthetic coevolution reveals adaptive mutational trajectories of neutralizing antibodies and SARS-CoV-2.Semantic proximity Read ↗

Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictableSemantic proximity Read ↗

Dissecting binding and immune evasion mechanisms for ultrapotent Class I and Class 4/1 neutralizing antibodies of SARS-CoV-2 spike protein using a multi-pronged computational approach: neutral frustration architecture of binding interfaces and immune escape hotspots drives adaptive evolution.Semantic proximity Read ↗

Disentangled multimodal evolutionary representations for cross-virus predictive modeling of antigenic changeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.