Article

Predicting Virus Fitness: Towards a structure-based computational model

2023-05-02

Abstract excerpt

Predicting the impact of new emerging virus mutations is of major interest in surveillance and for understanding the evolutionary forces of the pathogen. The SARS-CoV-2 surface spike-protein (S-protein) binds to human ACE2 receptors as a critical step in host cell infection. At the same time, S-protein binding to human antibodies neutralizes the virus and prevents interaction with ACE2. Here we combine these two b...

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Literature Corpus work: e1670d69-044e-5f2f-bed1-e753956fd94e
DOI: 10.1101/2023.05.01.538902

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