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Article

Biophysical principles predict fitness of SARS-CoV-2 variants.

Proceedings of the National Academy of Sciences of the United States of America - 4 Jun 2024

Wang Dianzhuo, Huot Marian, Mohanty Vaibhav, Shakhnovich Eugene I

Abstract excerpt

SARS-CoV-2 employs its spike protein's receptor binding domain (RBD) to enter host cells. The RBD is constantly subjected to immune responses, while requiring efficient binding to host cell receptors for successful infection. However, our understanding of how RBD's biophysical properties contribute to SARS-CoV-2's epidemiological fitness remains largely incomplete. Through a comprehensive approach, comprising...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38820002
DOI: 10.1073/pnas.2314518121
PMCID: PMC11161772

Genes

ACE2

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