Article
Epistatic hotspots organize antibody fitness landscape and boost evolvability.
Proceedings of the National Academy of Sciences of the United States of America - 14 Jan 2025
Schulz Steven, Tan Timothy J C, Wu Nicholas C, Wang Shenshen
Abstract excerpt
The course of evolution is strongly shaped by interaction between mutations. Such epistasis can yield rugged sequence-function maps and constrain the availability of adaptive paths. While theoretical intuition is often built on global statistics of large, homogeneous model landscapes, mutagenesis measurements necessarily probe a limited neighborhood of a reference genotype. It is unclear to what extent local...
Topics
- Epistasis, Genetic
- SARS-CoV-2
- Mutation
- Humans
- COVID-19
- Evolution, Molecular
- Genetic Fitness
- Genotype