Article

Dysfunctional HDL Promotes Platelet Apoptosis and Thrombosis in Familial Hypercholesterolemia

2025-03-28

Abstract excerpt

<h4>Background</h4> In familial hypercholesterolemia (FH), high-density lipoprotein (HDL) often becomes dysfunctional and enriched with lipid peroxidation products, potentially contributing to increased thrombotic risk. However, its specific effects on platelet function and thrombosis remain unclear. Whether targeting HDL oxidation can restore its protective role has yet to be determined. <h4>Methods</h4> Platelet...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8f68c42a-55d3-5b89-9f8f-142a5be472a3
DOI: 10.1101/2025.03.26.25324730

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dysfunctional HDL Promotes Platelet Apoptosis and Thrombosis in Familial HypercholesterolemiaDOI 10.1101/2025.03.26.25324730Read

Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype.Semantic proximity Read

Enhanced lipid peroxidation and platelet activation as potential contributors to increased cardiovascular risk in the low-HDL phenotype.Semantic proximity Read

Common anti-platelet therapies modulate procoagulant phospholipids in arterial diseaseSemantic proximity Read

Differential platelet oxidation-inflammatory phenotype in coronary artery disease versus peripheral artery disease supports diverse pathophysiological processesSemantic proximity Read

ALDH2 rs671 variant enhances platelet activation and thrombosis by disrupting mitochondrial complex I assembly.Semantic proximity Read

Maresin 1 induces a novel pro-resolving phenotype in human platelets.Semantic proximity Read

Oxidative Stress Triggers Defective Autophagy in Endothelial Cells: Role in Atherothrombosis DevelopmentSemantic proximity Read

Inhibitory effects of in vivo oxidized high-density lipoproteins on platelet aggregation: evidence from patients with abetalipoproteinemia.Semantic proximity Read

Lipoprotein(a) is associated with higher DNA damage in patients with heterozygous familial hypercholesterolemiaSemantic proximity Read

Regulation of platelet lifespan by apoptosisSemantic proximity Read

TLR2 Plays a Key Role in Platelet Hyperreactivity and Accelerated Thrombosis Associated With Hyperlipidemia.Semantic proximity Read

Triglyceride-rich HDL3 from patients with familial hypercholesterolemia are less able to inhibit cytokine release or to promote cholesterol efflux.Semantic proximity Read