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Article

TLR2 Plays a Key Role in Platelet Hyperreactivity and Accelerated Thrombosis Associated With Hyperlipidemia.

Circulation research - 29 Sept 2017

Biswas Sudipta, Zimman Alejandro, Gao Detao, Byzova Tatiana V, Podrez Eugene A

Abstract excerpt

RATIONALE: Platelet hyperreactivity, which is common in many pathological conditions, is associated with increased atherothrombotic risk. The mechanisms leading to platelet hyperreactivity are complex and not yet fully understood. OBJECTIVE: Platelet hyperreactivity and accelerated thrombosis, specifically in dyslipidemia, have been mechanistically linked to the accumulation in the circulation of a specific group...

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Topics

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Share to CD36 Antigens
Share to Hyperlipidemias
Share to Myeloid Differentiation Factor 88

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phospholipids

Share to Platelet Activation

Share to Thrombosis

Share to Toll-Like Receptor 2

Share to Toll-Like Receptor 6

Source

Open in PubMed Open full text

Identifiers

PMID: 28775078
DOI: 10.1161/CIRCRESAHA.117.311069
PMCID: PMC5623081

Genes

TLR2
TLR6
TIRAP
TNF
TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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