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Article

Enhanced lipid peroxidation and platelet activation as potential contributors to increased cardiovascular risk in the low-HDL phenotype.

Journal of the American Heart Association - 4 Apr 2013

Vazzana Natale, Ganci Antonina, Cefalù Angelo Baldassare, Lattanzio Stefano, Noto Davide, Santoro Nicole, Saggini Raoul, Puccetti Luca, Averna Maurizio, Davì Giovanni

Abstract excerpt

BACKGROUND: Low high-density lipoprotein (HDL) levels are major predictors of cardiovascular (CV) events, even in patients on statin treatment with low-density lipoprotein (LDL) at target. In animal models HDLs protect LDL from oxidation and blunt platelet activation. Our study aimed to examine whether HDL levels are related to in vivo oxidative stress and platelet activation, as determinants of atherothrombosis....

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Identifiers

PMID: 23557750
DOI: 10.1161/JAHA.113.000063
PMCID: PMC3647282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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