Article
Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype.
Nature medicine - 1 Sept 2007
Podrez Eugene A, Byzova Tatiana V, Febbraio Maria, Salomon Robert G, Ma Yi, Valiyaveettil Manojkumar, Poliakov Eugenia, Sun Mingjiang, Finton Paula J, Curtis Brian R, Chen Juhua, Zhang Renliang, Silverstein Roy L, Hazen Stanley L
Abstract excerpt
Dyslipidemia is associated with a prothrombotic phenotype; however, the mechanisms responsible for enhanced platelet reactivity remain unclear. Proatherosclerotic lipid abnormalities are associated with both enhanced oxidant stress and the generation of biologically active oxidized lipids, including potential ligands for the scavenger receptor CD36, a major platelet glycoprotein. Using multiple mouse in vivo...
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