Article

Common anti-platelet therapies modulate procoagulant phospholipids in arterial disease

2022-11-04

Abstract excerpt

Enzymatically oxygenated phospholipids (eoxPL) formed by lipoxygenases (LOX) and cyclooxygenase (COX) in platelets and leukocytes are pro-coagulant in multiple model systems. However, their generation in arterial thrombotic disease, and how their levels are modulated by common therapies is unknown. Here, eoxPL were first characterized in isolated platelets and leukocytes from an arterial vascular disease cohort, a...

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Literature Corpus work: 88a0b973-decc-5513-b3e6-6a2089185ed7
DOI: 10.1101/2022.11.03.22280948

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