Cultured human adult microglia from different donors display stable cytokine, chemokine and growth factor gene profiles but respond differently to a pro-inflammatory stimulus.

Abstract excerpt

OBJECTIVES: Brain microglia are highly responsive cells in the central nervous system that exert key functions in host defense as well as in neuroprotection and regeneration. In this study the gene expression profiles for 268 cytokines, chemokines, growth factors and their receptors were examined in cultures of purified human adult microglia, using cDNA array profiling. METHODS: Microglia from 9 different donors...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chemokines
• Share to Cytokines