Article

Drivers of Transcriptional Variance in Human Intestinal Epithelial Organoids

2021-06-03

Abstract excerpt

<h4>Background & Aims</h4> Human intestinal epithelial organoids (enteroids and colonoids) are tissue cultures used for understanding the physiology of the intestinal epithelium. Here, we explored the effect on the transcriptome of common variations in culture methods, including extracellular matrix substrate, format, tissue segment, differentiation status, and patient heterogeneity. <h4>Methods</h4> RNA-sequenc...

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Literature Corpus work: b806e5d0-4408-50c2-9ca0-8d6ad959df5b
DOI: 10.1101/2021.06.02.446644

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