Article
Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.
Nature - 25 Mar 2010
He Yiping, Wu Jian, Dressman Devin C, Iacobuzio-Donahue Christine, Markowitz Sanford D, Velculescu Victor E, Diaz Luis A, Kinzler Kenneth W, Vogelstein Bert, Papadopoulos Nickolas
Abstract excerpt
The presence of hundreds of copies of mitochondrial DNA (mtDNA) in each human cell poses a challenge for the complete characterization of mtDNA genomes by conventional sequencing technologies. Here we describe digital sequencing of mtDNA genomes with the use of massively parallel sequencing-by-synthesis approaches. Although the mtDNA of human cells is considered to be homogeneous, we found widespread...
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