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Article

Polar and charged extracellular residues conserved among barrier-forming claudins contribute to tight junction strand formation.

Annals of the New York Academy of Sciences - 1 Jun 2017

Piontek Anna, Rossa Jan, Protze Jonas, Wolburg Hartwig, Hempel Caroline, Günzel Dorothee, Krause Gerd, Piontek Jörg

Abstract excerpt

Claudins (Cldn) form the backbone of tight junction (TJ) strands and thereby regulate paracellular permeability for solutes and water. Polymeric strands are formed by homo- and heterophilic cis- and trans-interactions between claudin protomers. Crystal structures of some claudins have been resolved; however, the mechanism by which claudins assemble into TJ strands remains unclear. To elucidate strand...

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PMID: 28415153
DOI: 10.1111/nyas.13341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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