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Article

Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo-Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner.

Journal of molecular biology - 27 Mar 2020

Hempel C, Protze J, Altun E, Riebe B, Piontek A, Fromm A, Lee I M, Saleh T, Günzel D, Krause G, Piontek J

Abstract excerpt

Tight junctions regulate paracellular permeability size and charge selectively. Models have been proposed for the molecular architecture of tight junction strands and paracellular channels. However, they are not fully consistent with experimental and structural data. Here, we analysed the architecture of claudin-based tight junction strands and channels by cellular reconstitution of strands, structure-guided...

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PMID: 32142789
DOI: 10.1016/j.jmb.2020.02.034

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