Article

Early life DNA methylation profiles are indicative of age-related transcriptome changes

2019-02-24

Abstract excerpt

Alterations to cellular and molecular programs with brain aging result in cognitive impairment and susceptibility to neurodegenerative disease. Changes in DNA methylation patterns, an epigenetic modification required for various CNS functions, are observed with aging and can be prevented by anti-aging interventions, but the functional outcomes of altered methylation on transcriptome profiles are poorly understood...

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Literature Corpus work: bb9b39e6-433e-5a9c-9f30-8ca5a77ef82f
DOI: 10.1101/557892

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