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Article

Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh.

Nature neuroscience - 1 Oct 2009

Favaro Rebecca, Valotta Menella, Ferri Anna L M, Latorre Elisa, Mariani Jessica, Giachino Claudio, Lancini Cesare, Tosetti Valentina, Ottolenghi Sergio, Taylor Verdon, Nicolis Silvia K

Abstract excerpt

Neural stem cells (NSCs) are controlled by diffusible factors. The transcription factor Sox2 is expressed by NSCs and Sox2 mutations in humans cause defects in the brain and, in particular, in the hippocampus. We deleted Sox2 in the mouse embryonic brain. At birth, the mice showed minor brain defects; shortly afterwards, however, NSCs and neurogenesis were completely lost in the hippocampus, leading to dentate...

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Source

Identifiers

PMID: 19734891
DOI: 10.1038/nn.2397

Genes

SHH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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