Article

Spatial transcriptomic analysis of adult hippocampal neurogenesis in the human brain

2023-05-02

Abstract excerpt

<h4>ABSTRACT</h4> Using spatial transcriptomics and FISH, we detected very few cells expressing neural stem cell- and proliferation-specific genes in the human dentate gyrus (DG) from childhood to middle age. However, we observed at all ages a significant number of DG cells expressing the immature neuronal marker DCX . Across ages, the majority of these cells displayed an inhibitory phenotype, while the remainde...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3f8aea81-c6c2-5d11-a2ee-fd49fc6388b3
DOI: 10.1101/2023.05.02.539011

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial transcriptomic analysis of adult hippocampal neurogenesis in the human brainDOI 10.1101/2023.05.02.539011Read

Spatial and Molecular Progression of Neural Progenitor Cells in the Developing Human Dentate GyrusSemantic proximity Read

Integrative genomic analysis of early neurogenesis reveals a temporal genetic program for differentiation and specification of preplate and Cajal-Retzius neuronsSemantic proximity Read

A roadmap to human hippocampal neurogenesis in adulthood, aging and AD.Semantic proximity Read

Reconsidering neurogenetic indication in the human brain: Broad expression of doublecortin transcript in hippocampal and cortical cell populationsSemantic proximity Read

Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammationSemantic proximity Read

Variation of human neural stem cells generating organizer states <i>in vitro</i> before committing to cortical excitatory or inhibitory neuronal fatesSemantic proximity Read

A single cell transcriptomic analysis of human neocortical developmentSemantic proximity Read

Single-cell RNA-seq reveals dynamic transcriptome profiling in human early neural differentiationSemantic proximity Read

A conserved differentiation program facilitates inhibitory neuron production in the developing mouse and human cerebellumSemantic proximity Read

Comprehensive cell atlas of the first-trimester developing human brainSemantic proximity Read

Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury statesSemantic proximity Read

Molecular and cellular dynamics of the developing human neocortex at single-cell resolutionSemantic proximity Read