Article

Early postnatal CA3 hyperexcitability drives hippocampal development and epileptogenesis in SCN2A developmental and epileptic encephalopathy

2025-06-29

Abstract excerpt

Developmental and epileptic encephalopathies caused by pathogenic variants in SCN2A ( SCN2A -DEE), encoding the voltage-gated sodium channel Na v 1.2, present with early-life seizures, developmental delay, and increased mortality. Using a novel Scn2a p.A263V gain-of-function (GOF) mouse model, we demonstrate gene-dose and background-dependent phenotypes ranging from self-limited neonatal seizures to chronic ep...

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Literature Corpus work: 0e558d5d-2d19-5947-a358-a4c7e7aae070
DOI: 10.1101/2025.06.29.661458

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