Article

A Principled Framework for Using Correlated Traits to Improve Risk Prediction

2026-08-27

Abstract excerpt

<h4>Background</h4> Although many complex phenotypes and diseases are influenced by shared genetic and environmental factors, risk prediction methods typically rely on genetic information from a single trait, leaving a rich source of predictive information largely unexploited. Phenotypic correlations can potentially be used to improve the accuracy of polygenic scores (PGS), but the conditions under which correlat...

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Literature Corpus work: 8e73db7a-f60a-5818-bca1-805ef604611c
DOI: 10.64898/2026.08.23.746504

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