Article

R2ROC: An efficient method of comparing two or more correlated AUC from out-of-sample prediction using polygenic scores

2023-08-03

Abstract excerpt

Polygenic risk scores (PRSs) enable early prediction of disease risk. Evaluating PRS performance for binary traits commonly relies on the area under the receiver operating characteristic curve (AUC). However, the widely used DeLong’s method for comparative significance tests suffer from limitations, including computational time and the lack of a one-to-one mapping between test statistics based on AUC and R 2 . To...

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Literature Corpus work: cd6a20d9-10ed-5497-894d-3b7ea07e88c9
DOI: 10.1101/2023.08.01.551571

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