Article

Probing T-cell response by sequence-based probabilistic modeling

2020-12-18

Abstract excerpt

With the increasing ability to use high-throughput next-generation sequencing to quantify the diversity of the human T cell receptor (TCR) repertoire, the ability to use TCR sequences to infer antigen-specificity could greatly aid potential diagnostics and therapeutics. Here, we use a machine-learning approach known as Restricted Boltzmann Machine to develop a sequence-based inference approach to identify antigen-...

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Literature Corpus work: 8e65b27b-04c4-5e11-82d0-103929b9b232
DOI: 10.1101/2020.12.17.423283

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