Article

Expanding the definition of MHC Class I peptide binding promiscuity to support vaccine discovery across cancers with CARMEN

2025-05-10

Abstract excerpt

Promiscuity in T-cell antigen landscapes refers to the dual flexibility of peptides binding multiple MHC alleles and MHC alleles presenting diverse arrays of peptides. By understanding how neoantigens are shared across varied HLA backgrounds, promiscuity analysis can inform the selection of cancer-vaccine targets that reach a wider segment of the population and help refine patient stratification for diverse immuno...

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Literature Corpus work: 4f8081f3-bef6-5ac8-9117-52269d5e01a0
DOI: 10.1101/2025.05.08.651510

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