Article
Enhanced Activities of Blood Thiamine Diphosphatase and Monophosphatase in Alzheimer's Disease.
PloS one - 1 Jan 2017
Pan Xiaoli, Sang Shaoming, Fei Guoqiang, Jin Lirong, Liu Huimin, Wang Zhiliang, Wang Hui, Zhong Chunjiu
Abstract excerpt
BACKGROUND: Thiamine metabolites and activities of thiamine-dependent enzymes are impaired in Alzheimer's disease (AD). OBJECTIVE: To clarify the mechanism for the reduction of thiamine diphosphate (TDP), an active form of thiamine and critical coenzyme of glucose metabolism, in AD. METHODS: Forty-five AD patients clinically diagnosed and 38 age- and gender-matched control subjects without dementia were...
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