Article

STUB1 is an intracellular checkpoint for interferon gamma sensing

2020-12-15

Abstract excerpt

Immune checkpoint blockade (ICB) leads to durable and complete tumour regression in some patients but in others gives temporary, partial or no response. Accordingly, significant efforts are underway to identify tumour-intrinsic mechanisms underlying ICB resistance. <h4>Results: </h4> from a published CRISPR screen in a mouse model suggested that targeting STUB1, an E3 ligase involved in protein homeostasis, may ov...

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Literature Corpus work: 8e22df30-876f-5d61-998e-53a50d687cca
DOI: 10.1101/2020.12.14.420539

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