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STUB1/CHIP: New insights in cancer and immunity

26 Jul 2023

Abstract excerpt

The STUB1 gene (STIP1 homology and U-box-containing protein 1), located at 16q13.3, encodes the CHIP (carboxyl terminus of Hsc70-interacting protein), an essential E3 ligase involved in protein quality control. CHIP comprises three domains: an N-terminal tetratricopeptide repeat (TPR) domain, a middle coiled-coil domain, and a C-terminal U-box domain. It functions as a co-chaperone for heat shock protein (HSP)...

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Identifiers

PMID: 37506582
DOI: 10.1016/j.biopha.2023.115190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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