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Article

PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity

23 Feb 2024

Abstract excerpt

Cancer immunotherapies have demonstrated remarkable success; however, the majority of patients do not respond or develop resistance. Here, we conduct epigenetic gene-targeted CRISPR-Cas9 screens to identify epigenomic factors that limit CD8 + T cell-mediated anti-tumor immunity. We identify that PRMT1 suppresses interferon gamma (Ifnγ)-induced MHC-I expression, thus dampening CD8 + T cell-mediated killing....

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PMID: 38401121
DOI: 10.1016/j.celrep.2024.113831

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