Article

Interferon-induced lysosomal membrane permeabilization and death cause cDC1-deserts in tumors

2022-03-14

Abstract excerpt

<h4>ABSTRACT</h4> T cell immunity requires antigen capture by conventional dendritic cells (cDCs), digestion and transfer to draining lymph nodes for presentation to antigen-inexperienced T cells. cDCs type I excel as cancer-antigen presenting cells, due to their ability to phagocytose, slowly digest apoptotic cancer cells and translocate cancer antigens to the cytosol for loading to MHCI and cross-presentation t...

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Literature Corpus work: 2e8e369a-81ba-5e15-9abb-dc92862e6f63
DOI: 10.1101/2022.03.14.484263

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