Article

NEDD8 loss causes cancer vulnerability to immune checkpoint blockade in triple-negative breast cancer

2024-03-25

Abstract excerpt

<title>Abstract</title> <p>Immune checkpoint blockade therapy aims to activate the immune system to eliminate cancer cells. However, clinical benefits are only recorded in a subset of patients. Here, we leveraged genome-wide CRISPR/Cas9 screens in a Tumor-Immune co-Culture System focusing on triple-negative breast cancer. We revealed that NEDD8 loss caused a vulnerability to nivolumab. Genetic deletion of NEDD8 o...

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Literature Corpus work: 59429aaf-fc85-5f49-8191-b77fb5e1867f
DOI: 10.21203/rs.3.rs-2687913/v1

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