Article

Tumor-intrinsic Ist1 restricts IFNγ responsiveness to drive immune evasion in pancreatic cancer

2026-07-20

Abstract excerpt

<title>Abstract</title> <p> Tumour-cell-intrinsic mechanisms that determine whether immune encounter culminates in effective killing or immune escape remain incompletely understood, particularly in immune-refractory solid tumours such as pancreatic cancer. Here, through integrative analysis of CRISPR-based genetic screening datasets, we identify the endosomal sorting complex required for transport (ESCRT)-associ...

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Literature Corpus work: 4de149bc-7d4d-5a64-989d-8391781dae02
DOI: 10.21203/rs.3.rs-10348019/v1

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