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Article

Transcription factors in fibroblast plasticity and CAF heterogeneity.

Journal of experimental & clinical cancer research : CR - 20 Dec 2023

Melchionna Roberta, Trono Paola, Di Carlo Anna, Di Modugno Francesca, Nisticò Paola

Abstract excerpt

In recent years, research focused on the multifaceted landscape and functions of cancer-associated fibroblasts (CAFs) aimed to reveal their heterogeneity and identify commonalities across diverse tumors for more effective therapeutic targeting of pro-tumoral stromal microenvironment. However, a unified functional categorization of CAF subsets remains elusive, posing challenges for the development of targeted CAF...

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Identifiers

PMID: 38124183
DOI: 10.1186/s13046-023-02934-4
PMCID: PMC10731891

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