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Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer

14 Aug 2020

Abstract excerpt

Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays vital roles in modulating metabolism, immunity, and oncogenesis. ATF3 acts as a hub of the cellular adaptive-response network. Multiple extracellular signals, such as endoplasmic reticulum (ER) stress, cytokines, chemokines, and LPS, are connected to ATF3 induction. The function of ATF3 as a regulator of metabolism and...

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PMID: 32922364
DOI: 10.3389/fendo.2020.00556

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