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Bridging the tumor microenvironment: the pivotal role of cancer-associated fibroblasts in tumor cachexia development

14 Jul 2025

Abstract excerpt

Tumor cachexia represents a complex and multifaceted metabolic syndrome that profoundly affects the quality of life and survival rates of individuals. It is highly prevalent in advanced cancer patients and is characterized by severe weight loss, muscle wasting, and systemic inflammation. The tumor microenvironment (TME) is pivotal in cancer formation and progression, where cancer-associated fibroblasts (CAFs)...

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PMID: 40660208
DOI: 10.1186/s12943-025-02379-7

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