Article

Quantitative and large-scale investigation of human TCR-HLA Cross-Reactivity

2025-03-01

Abstract excerpt

The interaction between Human leukocyte antigens (HLA) and T cell receptor (TCR) is essential for adaptive immune recognition. While it is known that one TCR can map to multiple HLA alleles, the extent of this cross-reactivity remains poorly understood. Here, we introduce THNet, a TCR-based HLA similarity inference method, and performed a comprehensive analysis of HLA-TCR cross-reactivity. This method is built upo...

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Literature Corpus work: 8dea205c-644a-5cb6-b4e4-2720e299682a
DOI: 10.1101/2025.02.20.639349

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