Article

Predicting Peptide HLA-II Presentation Using Immunopeptidomics, Transcriptomics and Deep Multimodal Learning

2022-09-22

Abstract excerpt

<h4>ABSTRACT</h4> The human leukocyte antigen (HLA) class II proteins present peptides to CD4 + T cells through an interaction with T cell receptors (TCRs). Thus, HLA proteins are key players in shaping immunogenicity and immunodominance. Nevertheless, factors governing peptide presentation by HLA-II proteins are still poorly understood. To address this problem, we profiled the blood transcriptome and immunopept...

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Literature Corpus work: 3156b0de-79f5-559d-939e-ae3d4c61fcb5
DOI: 10.1101/2022.09.20.508681

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