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Article

Quantitative and large-scale investigation of human TCR-HLA cross-reactivity.

Science advances - 24 Oct 2025

Pan Mingyao, Tan Yuhao, Wang Yizhou Tracy, Hu Jing, Fleming Julia, Hu Hailong, Yang Ziqi, Zhan Xiaowei, Li Bo

Abstract excerpt

The interaction between human leukocyte antigens (HLAs) and T cell receptor (TCR) is essential for adaptive immune recognition. While it is known that one TCR can map to multiple HLA alleles, the extent of this cross-reactivity remains poorly understood. Here, we introduce THNet, a TCR-based HLA similarity network, and present a comprehensive analysis of HLA-TCR cross-reactivity, which is built upon more than 9...

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Identifiers

PMID: 41134880
DOI: 10.1126/sciadv.adx1751
PMCID: PMC12551698

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