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Systematic mining and quantification reveal the dominant contribution of non-HLA variations to acute graft-versus-host disease.

Cellular & molecular immunology - 1 May 2025

Liang Shuang, Kang Yu-Jian, Huo Mingrui, Yang De-Chang, Ling Min, Yue Keli, Wang Yu, Xu Lan-Ping, Zhang Xiao-Hui, Xia Chen-Rui, Li Jing-Yi, Wu Ning, Liu Ruoyang, Dong Xinyu, Liu Jiangying, Gao Ge, Huang Xiao-Jun

Abstract excerpt

Human leukocyte antigen (HLA) disparity between donors and recipients is a key determinant triggering intense alloreactivity, leading to a lethal complication, namely, acute graft-versus-host disease (aGVHD), after allogeneic transplantation. Moreover, aGVHD remains a cause of mortality after HLA-matched allogeneic transplantation. Protocols for HLA-haploidentical hematopoietic cell transplantation (haploHCT)...

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Identifiers

PMID: 40033084
DOI: 10.1038/s41423-025-01273-y
PMCID: PMC12041598

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