Article

Differential expression and modulation of presenilin-1 and presenilin-2 in neural cell lines

2024-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Presenilin proteins, the catalytic components of the γ-secretase enzyme, play a key role in the pathogenesis of Alzheimer’s disease primarily by generating amyloid-β peptides. Although often grouped together, Presenilin-1 (PS1) and Presenilin-2 (PS2) are distinct proteins that contribute differently to γ-secretase activity. This study examines the differential expression of PS1 and PS2 in variou...

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Literature Corpus work: 8de74dda-2b43-50ba-94b2-932d0cb64f67
DOI: 10.1101/2024.10.15.618376

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