Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies.

Journal of neuroscience research - 15 May 1999

Diehlmann A, Ida N, Weggen S, Grünberg J, Haass C, Masters C L, Bayer T A, Beyreuther K

Abstract excerpt

Because distinct mutations in presenilin 1 and presenilin 2 are a major cause of early-onset familial Alzheimer's disease, we generated four monoclonal antibodies for the identification, localization, and investigation of presenilins in various cell lines and tissues from patients and controls. W...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Specificity
Share to Astrocytes
Share to Cross Reactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Weight

Share to Organelles

Share to Plaque, Amyloid

Share to Presenilin-1

Share to Presenilin-2

Source

Identifiers

PMID: 10340748
DOI: 10.1002/(SICI)1097-4547(19990515)56:4<405::AID-JNR8>3.0.CO;2-F

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10340748-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies.PMID 10340748Read ↗

Differential expression and modulation of presenilin-1 and presenilin-2 in neural cell linesSemantic proximity Read ↗

Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine TissuesSemantic proximity Read ↗

The physiological role of presenilins in cellular differentiation: lessons from model organisms.Semantic proximity Read ↗

Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing.Semantic proximity Read ↗

Subcellular distribution and turnover of presenilins in transfected cells.Semantic proximity Read ↗

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.Semantic proximity Read ↗

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.Semantic proximity Read ↗

Endoproteolytic Cleavage and Proteasomal Degradation of Presenilin 2 in Transfected CellsSemantic proximity Read ↗

Expression of presenilin-1 and -2 mRNAs in rat and Alzheimer's disease brainsSemantic proximity Read ↗

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.Semantic proximity Read ↗

Mutational analysis of intrinsic regions of presenilin 2 that determine its endoproteolytic cleavage and pathological function.Semantic proximity Read ↗

Presenilins in the Developing, Adult, and Aging Cerebral CortexSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.