Article
Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.
The Journal of biological chemistry - 7 Nov 1997
Thinakaran G, Harris C L, Ratovitski T, Davenport F, Slunt H H, Price D L, Borchelt D R, Sisodia S S
Abstract excerpt
Mutations in two related genes, PS1 and PS2, account for the majority of early onset cases of familial Alzheimer's disease. PS1 and PS2 are homologous polytopic membrane proteins that are processed endoproteolytically into two fragments in vivo. In the present report we examine the fate of endoge...
Topics
- Animals
- Binding, Competitive
- Brain Chemistry
- Humans
- Membrane Proteins
- Mice
- Mice, Transgenic
- Molecular Weight
- Mutation
- Neuroblastoma
- Presenilin-1
- Presenilin-2
- Tumor Cells, Cultured